Individualized Medicine & Therapies
Individualized Medicine and Therapies is purposed to bring light to physicians, researchers, patients, and patients’ loved ones whose diagnoses and measurements are unique to the individual patient and those treatments and therapies that may help to return the individual patient not only to health but to wellness. We believe wellness includes reduced morbidity and mortality risks, reduced medication-load, and reduced hospitalizations and re-hospitalizations, all the while improving quality of life and productivity.
The Parasympathetic and Sympathetic (P&S) branches of the Autonomic nervous system have been characterized as an individual’s “physiologic fingerprint.” The P&S collectively control every organ and organ system in the body and virtually every cell within the human body, including the immune system. In fact, they provide the memory for the immune system, furthering the uniqueness to the individual. Health and wellness are established with a proper P&S balance at rest and proper P&S responses to challenge. While there are only a relative few P&S measurements, they apply to all situations. We have only one P&S system, but it must address all of our conditions, healthy or unhealthy. While this appears to generalize the P&S responses, and it does, when added to the patient’s history, symptomatology, lifestyle, and medication load, it becomes individualized. Information from P&S monitoring added to a patient’s history, medication load, lifestyle, and symptomatology helps to further specify a patient’s therapy plan. This plan may initially increase medication load, but usually decreases it as proper P&S balance and responses are re-established. Once re-established, the P&S nervous system “remembers” and is able to maintain that condition and carry forward until some new clinical event occurs.
P&S Monitoring is not “standard” Autonomic Nervous System (ANS) monitoring. ANS monitoring only measures total autonomic function, forcing assumption and approximation to theorize the underlying P&S activity. Total autonomic function is not only unable to directly measure P&S activity, but its assumptions and approximations prevent reliable follow-up testing because the assumptions and approximations are invalidated by therapy. P&S Monitoring has no assumptions and approximations, therefore it is able to measure an individual’s specific responses to disease and therapy in light of their lifestyle and history. In this way, therapy may be more appropriately titrated to the individual. P&S Monitoring also enables earlier detection and preventative proactive medicine, as well as emergency rescue medicine. The latter helps patients to return to health and the former helps to establish and maintain wellness.
Profile of Physicians
P&S Monitoring is the basis for and enables individualized medicine and provides additional information for all specialties and subspecialties in medicine. Other measurements specific to the various specialties and subspecialties customize this additional information.
Again, the P&S Nervous Systems control or coordinate all organs, organ systems, and virtually all cells in the human body. So, it is not unusual that virtually all areas of medicine would benefit from P&S Monitoring. Individual physicians from the following specialties and subspecialties have, or continue to, include individualized medicine and therapies in their practices: Cardiology, Chiropractic Medicine, Endocrinology, Family Medicine, Gastroenterology, Gynecology, Infectious Disease, Internal Medicine, Natural Medicine, Nephrology, Neurology, Oncology, Ophthalmology, Pain Medicine, Pulmonology, Reproductive Medicine, Rheumatology, Sleep Medicine, and more.
Gary L. Murray, MD, FACC, FICA, FASNC, FSCA
Dr. Murray was a board-certified Cardiologist who practiced in Memphis for more than 21 years. He graduated Rhodes College and Tulane University Medical School. He completed his residency and fellowship at the University of Tennessee Health Science Center, then served as Chief of Medical Services at Nellis Air Force Base.
Dr. Murray was the first Nuclear Cardiologist in Memphis and the first Cardiologist in Memphis to perform peripheral angioplasty and stenting. In addition, he was the co-creator of a software program called Schad Murray Functional Cardiac images, proclaimed by many of the leading cardiology clinics around the world as one of the most accurate non-invasive tests for detecting coronary artery blockages. Dr. Murray had done much original research and had published a variety of articles in peer-reviewed medical journals.
Gary L. Murray, MD, FACC, FICA, FASNC, FSCA
Founder, Contributor & First President (In Memoriam, 2021)
Nicholas L. DePace, MD, FACCC
Founder & President
Nicholas L. DePace, MD, FACCC
Dr. DePace developed an interest in Cardiovascular Medicine as early as the age of 12 after he witnessed his 53 year old uncle die of sudden cardiac arrest. He graduated from Nutley High School at the top of his class and then attended Seton Hall University where he also graduated summa cum laude as an undergraduate. He was accepted to the prestigious Mount Sinai School of Medicine, receiving his MD degree in 1978. Subsequently, He moved to Philadelphia for an internal medicine residency at Hahnemann University. He was chief medical resident in 1981 and completed his cardiovascular training at the Likoff Cardiovascular Institute in 1983. He obtained the rank of full clinical professor at the Medical College of Pa. at the age of 33, the youngest full professor at the time in Philadelphia. Dr. DePace was a prolific publisher and clinical researcher early in his career. He has also published extensively in noninvasive cardiology, specifically echocardiography and nuclear cardiology.
His early work on stress testing and assessing coronary artery disease contributed significantly to cardiology. He has authored and co-authored over 100 articles, abstracts, and textbook chapters. His national book, “The Heart Repair Manual, the Philadelphia Formula For Prevention and Reversal of Heart Disease" by W.W. Norton, NY, NY has been widely distributed. His Philadelphia Formula developed one of the first scoring systems in America to stratify coronary risk (before Framingham/ATP III). He also co-wrote a text book for Physicians in 2015 called “Clinical Autonomic Dysfunction: Measurements, Indications, Therapies and Outcomes” by Springer. He currently has an active research lab on Autonomic Dysfunction and is in the process of publishing new papers with Dr. Colombo with whom he co-wrote the book “Clinical Autonomic Dysfunction”. He has lectured and presented research papers here and abroad, including China, Israel, Africa, and Europe. Dr. DePace also was a health expert for the radio station 950 WPEN for 10 years on the 10 o’clock news hour.
Dr. DePace is board certified in Cardiovascular Disease, Internal Medicine, Echocardiography, Nuclear Medicine, and Lipidology. To our knowledge, he is the only physician in South Jersey that is board certified in Lipidology. His interest in Lipids began when he submitted a research abstract in 1987 while working with Omega 3 products designed by Tim Shields, Sr. of Rescue 1000. He currently is affiliated with Our Lady of Lourdes Hospital Cardiology Services, Kennedy Hospital-Washington Twp., and Hahnemann Hospital. He also teaches at Hahnemann Hospital where he holds positions as Professor of Medicine and Associate Chief of Cardiology at the Drexel Medical School/Hahnemann. He was Italian-American man of the year in 2004, he is in the Nutley, NJ hall of fame, and he has been named one of the best physicians in South Jersey Magazine in 2007, 2008, 2009, 2010, 2011, 2012, 2013, and 2015. He also was voted as one of America's most compassionate doctors for 2012 by Vitals Statistics and also received Philadelphia Magazine's Top Doctor awards for 2014 and 2015. His Franklin Cardiovascular Associates offices are located in Sicklerville, NJ. He is also the owner/operator of several South Jersey Urgent care centers.
Joseph Colombo, PhD, DNM, DHS
Dr. Colombo is trained in neurology with a background in electrical and mechanical engineering. His focus is Neuro-Cardiology. His doctorate from University of Rochester Medical School, NY, is in Neuroscience and Biomedical Engineering. Dr. Colombo currently serves as Chief Technology Officer and Senior Medical Director of Physio PS, Inc. and Parasympathetic & Sympathetic Nervous System Consultant, Franklin Cardiovascular Associates, PA. He is licensed as a Doctor of Natural Medicine and a Doctor of Humanitarian Services. He is a board member of Ansar, Inc. He has been an adjunct professor in medicine and lectures world-wide on clinical applications of, and disorders and treatments of, the Parasympathetic and Sympathetic (P&S) nervous systems. His career has included developing sensory-neural prostheses, including: digital hearing aids, cochlear implants, cochlear nucleus implants, visual prostheses, and vestibular measures; and over 30 years developing aircraft crew systems and life support systems for NASA, DoD, and FAA. He is a signal processing expert. He has also been involved in developing tele-healthcare, tele-medicine, and tele-psychiatry systems. For over 25 years, Dr. Colombo has developed P&S nervous system technologies and has researched and published clinical applications and outcome studies in uses of non-invasive P&S monitoring in critical care (trauma and sepsis), anesthesiology, cardiology, endocrinology, family medicine, internal medicine, pain management, neurology, neonatology, pediatrics, psychiatry, pulmonology, sleep medicine, and more as positive, patient outcomes data are available. He has (co-)authored over 100 journal articles internationally, and has ghost-written over 100 more. He has also (co-)authored book chapters and medical textbooks on clinical applications of, and outcomes from, non-invasive P&S guided therapy. Dr. Colombo continues to participate in more than 50 clinical research projects world-wide and consults with physicians, clinically, on a global scale. He has a wife of almost 40 years and two married children, and a grandchild, with over 30 years of mentoring hundreds of youths and students, including medical students.
Joseph Colombo, PhD, DNM, DHS
Founder & Chief Editor
Steve O’Leary is a business executive with a rare blend of technical and sales acumen which he has used to build world-class sales and marketing teams for global companies. He helped developed the HIPAA legislation and has detailed knowledge of the security requirements within the medical industry. Steve has a proven communication history for managing teams and giving successful presentations that build client relationships.
P&S Monitoring is the basis for, and enables, individualized medicine and provides additional information for all specialties and subspecialties in medicine. Other measurements specific to the various specialties and subspecialties customizes this additional information.
Again, the P&S Nervous System control or coordinate all organs, organ systems, and virtually all cells in the human body. So, it is not unusual that virtually all areas of medicine would benefit from P&S Monitoring. Individual physician s from the following specialties and subspecialties have, or continue to, include individualized medicine and therapies in their practices: Cardiology, Chiropractic Medicine, Endocrinology, Family Medicine, Gastroenterology, Gynecology, Infectious Disease, Internal Medicine, Natural Medicine, Nephrology, Neurology, Oncology, Ophthalmology, Pain Medicine, Pulmonology, Reproductive Medicine, Rheumatology, Sleep Medicine, and more.