Hypermobility/Ehlers-Danlos Syndrome and the Parasympathetic and Sympathetic Nervous Systems

Introduction. Ehlers-Danlos Syndrome/Hypermobility (EDSh) patients they demonstrate some degree of autonomic dysfunction (a.k.a., dysautonomia). In general, dysautonomia is the effect of an imbalance between the two autonomic branches: the Parasympathetic and Sympathetic (P&S) nervous systems. Methods. From a suburban cariology and autonomic clinic (Sicklerville, NJ) drawing patients from around the world, a cohort of 243 patients (223 female, 91.8%; average age 34.0 yrs, range 13 to 65 y/o; average BMI 27.3#/in2) previously diagnosed by Rheumatology with EDSh were followed from between November 2018 through May 2020. Baseline and at least two follow-up autonomic tests, with questionnaires, were administered. Results. While the etiology of EDSh is still being studied, the autonomic dysfunction, specifically both Parasympathetic and Sympathetic dysfunction caused by the results of the connective tissue disorder, may be documented, diagnosed, and treated. Conclusion. This is just the beginning of a research effort that must include many more patients from many more sources as EDSh awareness continues to grow.